Charles Loprinzi, MD of Mayo Clinic, Rochester, MN discusses neuropathy treatment options. ASCO guidelines recommend duloxetine, an antidepressant medication, which helps but does not completely eliminate the neuropathic pain. A scrambler therapy, developed for patients with chronic pain, is another option. This therapy may reduce the neuropathic pain by up to 50%, as suggested by a study conducted by dr Thomas Smith. Scrambler therapy is an electrocutaneous treatment used daily for ten days, with a potential to eliminate neuropathic pain in patients for weeks, months, or even years. Dr Loprinzi mentions, however, that the treatment does not work in all patients, and booster treatments may be required. Recorded at the Multinational Association of Supportive Care in Cancer (MASCC) and International Society of Ocular Oncology (ISOO) 2016 Annual Meeting on Supportive Care in Cancer held in Adelaide, Australia.