Thorsten O. Goetze, MD, University Cancer Center Frankfurt, Frankfurt, Germany, outlines the changing treatment landscape of patients with gastrointestinal malignancies including combining chemotherapy and immune checkpoint blockade, emerging targeted therapies including the FGFR inhibitor bemarituzumab, as well as HER2-targeting agents in patients with HER2 alternations. This interview took place at the American Society of Clinical Oncology (ASCO) 2021 Virtual Meeting.