Anwaar Saeed, MD, University of Kansas Medical Center, Kansas City, MO, discusses the rationale behind the CAMILLA trial (NCT03539822), which investigated the combination of cabozantinib, a tyrosine kinase inhibitor (TKI), with durvalumab, a PD-L1 inhibitor, in patients with gastric cancer, esophageal adenocarcinoma, hepatocellular carcinoma, and colorectal cancer. The trial focused on patients with stage 3 and 4 microsatellite-stable disease. This interview took place during the 36th Society for Immunotherapy of Cancer (SITC) Annual Meeting in Washington, D.C.