Kohei Shitara, MD, National Cancer Center Hospital East, Kashiwa, Japan, discusses the use of antibody-drug conjugates (ADCs) in the treatment of solid tumors. The tumor agnostic Phase II DESTINY-PanTumor-02 (NCT04482309) trial investigated trastuzumab deruxtecan (T-DXd) in patients with gastric or gastroesophageal junction (mG/GEJ) adenocarcinoma with HER-2 expression. Tumor agnostic approaches are possible with ADCs and have shown high response rates. Another trial, the Phase I/II TROPION-PanTumor02 (NCT05460273) study, is investigating the use of a bispecific ADC and has demonstrated impressive response rates for lung cancer and other malignancies. Finally, Dr Shitara, highlights the transmembrane protein, CDCP1, as a new target for small cell lung cancer (SCLC) due to tumor-specific expression. This data is encouraging for the use of ADCs in the treatment of a variety of cancers. This interview took place at the American Society of Clinical Oncology (ASCO) 2023 Annual Congress in Chicago, IL.
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