Petros Grivas, MD, PhD, University of Washington and Fred Hutchinson Cancer Research Center, Seattle, WA, provides an overview of a study evaluating the association of RB1 mutational status with overall genomic landscape in patients with neuroendocrine prostate cancer (NEPC). This interview took place at the American Society of Clinical Oncology (ASCO) Genitourinary Cancers Symposium 2022 in San Francisco, CA.