WCLC 2023 | Prognostic molecular and genetic factors for NSCLC

Akif Turna, MD, PhD, Istanbul University-Cerrahpasa, Istanbul, Turkey, discusses prognostic molecular and genetic factors for non-small cell lung cancer (NSCLC). Prognosis is crucial in NSCLC as accurate predictions can facilitate the selection of operable patients and provide valuable information for the post-operation period. Whilst the TNM system is a good prognostic method, it is not always effective for all patients with NSCLC. Molecular and genetic factors are important in defining a tumour’s biological behaviour, hence it is advisable to utilise them in prognosis. Two prognostic indicators of interest are EGFR and the tumour necrosis factor-related apoptosis-inducing ligand-receptor (TRAIL) gene. The TRAIL gene and its isoforms have been shown to be related to some pathological features such as lymphovascular invasion. Prof. Turna comments on a new staging system soon to be released that may complement molecular markers. This interview took place at the 2023 World Conference on Lung Cancer (WCLC) in Singapore, Singapore.

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