BNOS 2022 | Treating glioblastoma with boron neutron capture therapy

Kendall Morrison, PhD, TAE Life Sciences, Santa Monica, CA, gives an overview of boron neutron capture therapy (BNCT), a non-invasive radiotherapeutic technique that utilizes boron to target tumors. First conceived in the 1930s, initial attempts with boric acid and subsequent bombardment of neutrons to treat the tumor were unsuccessful due to surrounding healthy tissue being damaged. Alternative sources of boron such as boronophenylalanine (BPA) and sodium borocaptate (BSH) additionally failed to yield promising results. However Dr Morrison highlights the advent of novel boronated compounds and neutron sources, making BNCT an attractive method to treat glioblastoma. This interview took place at the British Neuro-Oncology Society (BNOS) Annual Meeting 2022.