Roger Li, MD, Moffitt Cancer Center, Tampa, FL, discusses the CORE1 trial (NCT04387461), a Phase II single-arm trial of the adenovirus oncolytic virus CG0070 plus pembrolizumab in patients with Bacillus Calmette-Guerin (BCG)-unresponsive carcinoma-in-situ bladder cancer. The primary endpoint was complete response rate (CR) at 12 months, determined via bladder biopsy. 20/22 patients achieved CR at 3 months and 6/8 patients achieved CR at 12 months. This interview took place at the American Urological Association annual congress 2022 in New Orleans and online.