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ESSO 45 | Propensity score matching outcomes in mesenteric peritonectomy

Francesca Nava • 4 Nov 2026
ESSO 45
Gastrointestinal Cancer

Francesca Nava, MD, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy, comments on the use of propensity score matching as a method to approximate randomized trial conditions in a retrospective analysis assessing mesenteric peritonectomy for peritoneal surface malignancies. While some imbalance remained due to small patient groups and multiple variables, sex and previous surgical score were excluded to optimize the analysis. The findings reveal no significant differences between the two groups except for longer surgical times and a higher risk of small bowel resections, with most resections occurring in zone 12, the terminal ileum typically removed with the right colon. This interview took place at the 2026 European Society of Surgical Oncology (ESSO) Annual Meeting in Madrid, Spain.

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Transcript

We could not randomize patients to do this analysis. So, the propensity SCORE match was actually what came closest to having a randomized trial. Of course, it is retrospective and the variables to match the patients were decided a priori. But besides that, it’s actually the only thing that came to mind to have an actual confrontation between patient groups...
We could not randomize patients to do this analysis. So, the propensity SCORE match was actually what came closest to having a randomized trial. Of course, it is retrospective and the variables to match the patients were decided a priori. But besides that, it’s actually the only thing that came to mind to have an actual confrontation between patient groups. It is not perfect. There is still some imbalance, considering there are, like, small patient groups and lots of variables. But what came out is actually that the biggest imbalance remained for sex and previous surgical SCORE. And we decided to STRIKE them out to have the best analysis possible. And what came out from this analysis is that, in fact, there is no big difference between the two groups besides longer surgeries and higher risk of resections of the small bowels. But it is important to underline that, in most cases, these resections happened in zone 12, which is usually the last bit of the smaller bowel that gets taken out with the right colon.

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