ASCO 2024 | TACT-D: a randomized study evaluating tailoring of mCRC therapy using ctDNA

Kanwal Pratap Singh Raghav, MBBS, MD, The University of Texas MD Anderson Cancer Center, Houston, TX, discusses the TACT-D study (NCT03844620), which evaluates early dynamic changes in circulating tumor DNA (ctDNA) to predict treatment response in metastatic colorectal cancer (mCRC). This randomized study aimed to validate ctDNA changes as indicators of treatment efficacy and adverse events with regorafenib or TAS102. Results showed that baseline ctDNA levels were strongly prognostic of clinical benefit. While the primary endpoints—treatment-related adverse events and objective response rate—showed no significant differences, adjustments for baseline ctDNA revealed that changes in ctDNA were predictive of progression-free and overall survival. These findings suggest the potential of ctDNA monitoring for optimizing mCRC treatment strategies. This interview took place during the 2024 American Society of Clinical Oncology (ASCO) Meeting in Chicago, IL.

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