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ESMO 2025 | The future role of active surveillance in pancreatic neuroendocrine tumors

Stefano Partelli, MD, Vita-Salute San Raffaele University, Milan, Italy, comments on the management of asymptomatic pancreatic neuroendocrine tumors (PanNETs), suggesting that active surveillance should be considered first. However, in rare cases with signs of aggressiveness, such as dilatation of the main pancreatic duct, where surgery is recommended. Active surveillance is a safe approach for most patients, and the protocol used in the ASPEN study (NCT03084770) allowed for timely intervention in cases of early progression. This interview took place at the European Society for Medical Oncology (ESMO) 2025 Congress in Berlin, Germany.

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Transcript

Well the best imaging modality is MRI because of the need to perform many of these imagings during the follow-up so in order to avoid the exposure of the patients to the x-rays. Again the only sign that should be considered a warning sign is the dilatation of the pancreatoduodenal or pancreatic duct, more commonly referred to as the ampulla or the pancreatic duct, however the term used was medipancreatic duct, a more precise term is the main pancreatic duct...

Well the best imaging modality is MRI because of the need to perform many of these imagings during the follow-up so in order to avoid the exposure of the patients to the x-rays. Again the only sign that should be considered a warning sign is the dilatation of the pancreatoduodenal or pancreatic duct, more commonly referred to as the ampulla or the pancreatic duct, however the term used was medipancreatic duct, a more precise term is the main pancreatic duct. We observed that some patients had already presented this type of feature, this dilatation, and other patients developed dilatation during the follow-up. So the first sign to look at is this and the second of course is the tumor growth. When the tumor increases in size and particularly when it reaches two centimeters or above then it’s time for surgery.

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