AACR 2023 | GLIMMER-01: E-602, a first-in-class bi-sialidase, in solid tumors

Jason Luke, MD, FACP, University of Pittsburgh Medical Center, Pittsburgh, PA, provides an overview of the Phase I/II GLIMMER-01 (NCT05259696) trial of E-602 in solid tumors. E-602 is composed of two engineered human sialidase molecules fused to a human monoclonal antibody. Preclinical studies have demonstrated that E-602 degrades terminal sialic acids on immunosuppressive sialoglycans on both tumor cells and immune cells, restoring both innate and adaptive antitumor immunity. The Phase I portion of the study consists of dose escalation cohorts of E-602 as a monotherapy and in combination with cemiplimab and includes subjects with melanoma, ovarian cancer, non-small cell lung cancer (NSCLC), colorectal cancer, pancreatic cancer, breast cancer, gastric/esophagogastric junction (EGJ) cancer, head and neck cancer, or urothelial cancer. The primary endpoints are dose limiting toxicities and safety. Key secondary endpoints include objective response rate (ORR), duration of response (DOR), progression-free survival (PFS) and overall-survival (OS). This interview took place at the American Association for Cancer Research (AACR) Annual Meeting 2023 in Orlando, FL.

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