Icro Meattini, MD, University of Florence, Florence, Italy, discusses important considerations for radiation oncologists for patients undergoing chest wall irradiation plus mastectomy and reconstructive surgery for breast cancer. Dr Meattini also discusses the recently published ESTRO guidelines on dose fractionation for external beam radiotherapy for patients with early breast cancer, as well as important policy considerations for the future of breast cancer. This interview took place at the European Society for Radiotherapy and Oncology (ESTRO) 2022 annual congress in Copenhagen, Denmark, and online.