Galina Velikova, MD, PhD, St. James’s University Hospital Leeds, Leeds, UK, talks on the main issues with late chemotherapy toxicities, including neuropathy, fatigue and, for younger patients, early menopause. Dr Velikova also discusses side effects of endocrine treatment. Importantly, adherence to treatment is dependent on improving the control of side effects. This interview took place at the European Society for Medical Oncology (ESMO) Breast Cancer 2022 congress in Berlin, Germany.