Educational content on VJOncology is intended for healthcare professionals only. By visiting this website and accessing this information you confirm that you are a healthcare professional.

Share this video  

ASCO 2025 | The emergence of ctDNA as a monitoring tool for endometrial cancer

Shannon Westin, MD, FASCO, The University of Texas MD Anderson Cancer Center, and GOG-F, Houston, TX, discusses the potential role of circulating tumor DNA (ctDNA) in the real-time monitoring and treatment personalization for patients with endometrial cancer. With the accumulating evidence across cancer types, including the Phase III DUO-E (NCT04269200) study, ctDNA shows substantial promise to refine treatment strategies and clinical decision-making for endometrial cancer care. This interview took place at the 2025 American Society of Clinical Oncology (ASCO) meeting in Chicago, IL.

These works are owned by Magdalen Medical Publishing (MMP) and are protected by copyright laws and treaties around the world. All rights are reserved.

Transcript

Yeah, I mean, I think, you know, the cool thing about ctDNA is obviously something that’s being looked at across all solid tumors. We haven’t had as many studies in endometrial cancer, and to my knowledge, this report from DUO-E is one of the first reports of ctDNA in a large phase three randomized study in the advanced and recurrent settings, so we’re happy to add to the literature there...

Yeah, I mean, I think, you know, the cool thing about ctDNA is obviously something that’s being looked at across all solid tumors. We haven’t had as many studies in endometrial cancer, and to my knowledge, this report from DUO-E is one of the first reports of ctDNA in a large phase three randomized study in the advanced and recurrent settings, so we’re happy to add to the literature there. I think broadly across cancer in general, utilizing ctDNA for monitoring and for understanding response to therapy is increasing. And so we’ve definitely needed more research in this space to truly understand how it might help guide decision making around is a patient, does a patient need more therapy? Or does a patient, you know, are they getting benefit from the therapy? Or do we need to move on to a different therapy? So I don’t know that we’re quite there yet. But I think this study in addition to other studies that are starting to report out will really help us understand the importance of ctDNA monitoring and how it might be used in clinical practice.

This transcript is AI-generated. While we strive for accuracy, please verify this copy with the video.

Read more...