Timothy Yap, MBBS, PhD, FRCP, The University of Texas MD Anderson Cancer Center, Houston, TX, explores findings from a Phase I trial (NCT04170153) of tuvusertib, an oral ATR inhibitor, with niraparib in patients with metastatic or locally advanced unresectable solid tumors. Tuvusertib and niraparib, administered in a one week on and one week off schedule, showed a manageable safety profile and promising efficacy in various cancer types, including PARP inhibitor-resistant tumors. This combination will be further explored in cases resistant to PARP inhibitors in the advanced ovarian cancer setting during the D-DRAIVER Ovarian 302 trial (NCT05216250). This interview took place during the 2024 American Society of Clinical Oncology (ASCO) Meeting in Chicago, IL.
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