Jeffrey Weber, MD, PhD, NYU Langone Medical Center, New York City, NY, discusses the results from a study making an indirect treatment comparison of adjuvant nivolumab versus placebo in patents with high-risk resected melanoma. This analysis used data from the phase III CheckMate 238 (NCT02388906) trial comparing nivolumab and ipilimumab and from the EORTC 18071 trial (NCT00636168) comparing ipilimumab vs placebo. Results showed that nivolumab was associated with clinically meaningful improvements in recurrence-free survival (RFS), distant metastasis-free survival (DMFS) and overall survival (OS) in comparison to placebo in this patient population. This interview took place during the 36th Society for Immunotherapy of Cancer (SITC) Annual Meeting in Washington, D.C.