Philip Poortmans, MD, PhD, AZ Sint-Augustinus – Oncologisch Centrum GZA – Iridium Kankernetwerk, Antwerpen, Belgium, talks on whether treatment in early-stage HER2-positive breast cancer should be modified, highlighting de-escalation of locregional approaches. This interview took place at the European Society for Medical Oncology (ESMO) Breast Cancer 2022 congress in Berlin, Germany.