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ESMO Asia 2023 | SRH-1701 for NSCLC treatment
Beung Chul Ahn, MD, National Cancer Center, Seoul, South Korea, summarizes the results of the Phase I trial (NCT05179239) assessing SHR-1701 in non-small cell lung cancer (NSCLC); the bifunctional fusion protein comprises an anti-PD-L1 antibody fused to the extracellular domain of the TGF-β receptor and is effective at blocking both respective pathways. TGF-β action has immunosuppressive functions that can contribute to cancer progression, so the focus of this study is to reshape the tumour microenvironment such that progression is not actively encouraged. SHR-1701 shows promising results and consideration for further studies as previous attempts at TGF-β inhibition have not been successful in previous trials, the challenge researchers are now presented with is the prevalence of treatment-related adverse events. This interview took place at the European Society for Medical Oncology (ESMO) Asia 2023 Congress in Singapore.
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