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ASCO GI 2025 | Evaluating the side effects of 2L treatment for upper gastrointestinal cancer

Timothy Brown, MD, UT Southwestern Medical Center, Dallas, TX, highlights the importance of dialogue between patients and clinicians regarding the side effects and treatment logistics when choosing a second-line treatment for upper gastrointestinal cancer. While ramucirumab with FOLFIRI or paclitaxel are second-line options for patients with minimal neuropathy from first-line treatment, Dr Brown encourages these patients with to opt for FOLFIRI with ramucirumab, which has fewer side effects without reducing second-line survival benefit. This interview took place at the ASCO GI Cancers Symposium 2025 in San Francisco, CA.

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