ASCO 2025 | Management of lifileucel-related cytopenias in patients with melanoma
James Smithy, MD, MHS, Memorial Sloan Kettering Cancer Center, New York, NY, comments on the importance of monitoring patients with melanoma treated with lifileucel post-discharge, Cytopenias, including thrombocytopenia and anemia, can occur, which may require repeated (complete blood count) CBC checks and blood transfusions. Adapting a follow-up plan based on the patient’s condition upon discharge is crucial. This interview took place during the 2025 American Society of Clinical Oncology (ASCO) Meeting in Chicago, IL.
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Transcript
I think the thing that did emerge were cytopenias and both thrombocytopenia and anemia. And so some patients needing repeated CBC checks and blood transfusions was something to keep an eye on. But again, all of that was fairly predictable at the time of hospital discharge. And so adapting your follow-up plan based on how a patient’s condition is doing when they go home is probably the way to adapt this...
I think the thing that did emerge were cytopenias and both thrombocytopenia and anemia. And so some patients needing repeated CBC checks and blood transfusions was something to keep an eye on. But again, all of that was fairly predictable at the time of hospital discharge. And so adapting your follow-up plan based on how a patient’s condition is doing when they go home is probably the way to adapt this.
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Disclosures
Consulting or Advisory Role – Bristol-Myers Squibb; IO Biotech; Iovance Biotherapeutics
Research Funding – Daiichi Sankyo (Inst); IO Biotech (Inst); Regeneron (Inst)
Travel, Accommodations, Expenses – Immatics
