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ASCO 2025 | CDK4/6 inhibitor switching in HR+/HER2- metastatic breast cancer

Paola Zagami, MD, European Institute of Oncology IRCSS (IEO), Milan, Italy, comments on the potential for switching CDK4/6 inhibitors in HR+/HER2- metastatic breast cancer, highlighting the importance of this approach in minimizing treatment interruptions due to adverse events. The FDA indication allows for long-term use of first-line treatment without frequent switches, and this approach is currently crucial for oncologists, as it can improve patient outcomes and quality of life. This interview took place during the 2025 American Society of Clinical Oncology (ASCO) Meeting in Chicago, IL.

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Transcript

This is again a study based on patients with aromatase receptor-positive breast cancer, but in this case it is metastatic breast cancer. We studied how the physicians and oncologists were thinking about the possibility of switching CDK4/6 from one to another only when there was a toxicity that was inaccessible. So the importance of this study is the physician was very proud about the FDA indication because you can use the first-line treatment for a long time and you have not to stop based on the adverse events...

This is again a study based on patients with aromatase receptor-positive breast cancer, but in this case it is metastatic breast cancer. We studied how the physicians and oncologists were thinking about the possibility of switching CDK4/6 from one to another only when there was a toxicity that was inaccessible. So the importance of this study is the physician was very proud about the FDA indication because you can use the first-line treatment for a long time and you have not to stop based on the adverse events. So this is another important point for the oncologist at this moment.

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