Educational content on VJOncology is intended for healthcare professionals only. By visiting this website and accessing this information you confirm that you are a healthcare professional.

Share this video  

ASCO 2025 | Biomarkers to guide MDR and hormonal treatment choice in prostate cancer

Eric Bent, MD, PhD, Memorial Sloan-Kettering Cancer Center, Cambridge, MA, illuminates the future use of biomarkers that promise an enhanced, more precise prostate cancer treatment regime to determine which patients would benefit from metastasis directed radiation (MDR) alone versus alongside hormonal therapy. Clinical data shows patients with oligometastatic prostate cancer benefiting from a combined therapy approach. However, the challenge of determining what biomarkers predict what patient population each treatment regime would benefit remains a significant hurdle, thus making doctors and researchers continuously reliant on clinical characteristics to determine treatment plan. This interview took place during the 2025 American Society of Clinical Oncology (ASCO) Meeting in Chicago, IL.

These works are owned by Magdalen Medical Publishing (MMP) and are protected by copyright laws and treaties around the world. All rights are reserved.

Transcript

The use of biomarkers to determine which patients benefit from metastasis-directed radiation and which patients might benefit from the addition of hormonal therapy to metastasis-directed radiation I think is a really important question for the field. We are planning in the future additional biomarker analysis. I think that the jury is still out on what biomarkers might predict who would or would not benefit...

The use of biomarkers to determine which patients benefit from metastasis-directed radiation and which patients might benefit from the addition of hormonal therapy to metastasis-directed radiation I think is a really important question for the field. We are planning in the future additional biomarker analysis. I think that the jury is still out on what biomarkers might predict who would or would not benefit. Right now, I’m mostly looking at clinical characteristics as a key determinant. But I do think that the data suggests so far that most patients with low-volume oligometastatic prostate cancer may benefit from radiation in combination with hormonal therapy.

This transcript is AI-generated. While we strive for accuracy, please verify this copy with the video.

Read more...