The Lung Cancer Channel is supported with funding from Johnson & Johnson (Gold) and Takeda (Gold).
VJOncology is an independent medical education platform. Supporters, including channel supporters, have no influence over the production of content. The levels of sponsorship listed are reflective of the amount of funding given to support the channel.
WCLC 2025 | Understanding the interaction of gene & environment in mesothelioma
Michele Carbone, MD, PhD, University of Hawaii Cancer Center, Honolulu, HI, discusses the increased susceptibility of individuals carrying germline mutations in DNA repair genes to environmental carcinogens in mesothelioma. These mutations impair the body’s ability to repair DNA damage, making individuals more vulnerable to the effects of environmental carcinogens. This increased susceptibility is particularly relevant for individuals carrying mutations in genes such as BAP1, TP53, and BRCA1. This interview took place at 2025 World Conference on Lung Cancer (WCLC) in Barcelona, Spain.
These works are owned by Magdalen Medical Publishing (MMP) and are protected by copyright laws and treaties around the world. All rights are reserved.
Transcript
Well, of course, if you carry a germline mutation of BAP1 or of any other gene, you are going to be, these are DNA repair genes. So you’re more susceptible to DNA damage. Carcinogens, such as environmental carcinogens, cause DNA damage. So you’re more susceptible to the carcinogenic effect of the carcinogens because you cannot fix your DNA. So people who can carry, for example, a BAP1 mutation or mutations of TP53 or BRCA1 and so on, their level of susceptibility to an environmental carcinogen is higher than for most of us...
Well, of course, if you carry a germline mutation of BAP1 or of any other gene, you are going to be, these are DNA repair genes. So you’re more susceptible to DNA damage. Carcinogens, such as environmental carcinogens, cause DNA damage. So you’re more susceptible to the carcinogenic effect of the carcinogens because you cannot fix your DNA. So people who can carry, for example, a BAP1 mutation or mutations of TP53 or BRCA1 and so on, their level of susceptibility to an environmental carcinogen is higher than for most of us.
This transcript is AI-generated. While we strive for accuracy, please verify this copy with the video.
Read more...
