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GU Cancers 2026 | How can miR-371 guide treatment decisions in testicular cancer?

Ben Tran, MBBS, FACP, Peter MacCallum Cancer Centre, Melbourne, Australia, describes the potential of miR-371 to optimize decision-making in the management of testicular cancer, highlighting its ability to identify those at high risk of recurrence who may benefit from adjuvant chemotherapy. Patients with positive miR-371 results may require more aggressive treatment, while those with negative results may have a lower risk of recurrence, potentially allowing for reduced surveillance imaging. This interview took place at the 2026 ASCO GU Cancers Symposium in San Francisco, CA.

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Transcript

Yeah, so at the moment, there are clearly clinicians with some biases towards active surveillance or towards adjuvant chemotherapy. And we hope that a microRNA 371 can optimize that decision-making. So if it’s positive, given that we’ve demonstrated that it increases the risk of recurrence, that is the population that may benefit from adjuvant chemotherapy, but we need to design clinical trials to prove that...

Yeah, so at the moment, there are clearly clinicians with some biases towards active surveillance or towards adjuvant chemotherapy. And we hope that a microRNA 371 can optimize that decision-making. So if it’s positive, given that we’ve demonstrated that it increases the risk of recurrence, that is the population that may benefit from adjuvant chemotherapy, but we need to design clinical trials to prove that. In the patients who are negative for microRNA 371, we can see that their risk of recurrence is very low. So the question there would be, can we kind of reduce the number of CT scans and imaging that we’re doing as part of surveillance?

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