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ASCO 2026 | Treatment sequencing after EV plus pembrolizumab in metastatic bladder cancer

Tian Zhang, MD, of UT Southwestern Medical Center, discusses evolving treatment sequencing strategies following frontline enfortumab vedotin (EV) plus pembrolizumab in metastatic bladder cancer, highlighting mechanisms of antibody-drug conjugate (ADC) resistance and the emerging role of alternative targets including TROP2 and HER2. This interview took place during the 2026 American Society of Clinical Oncology (ASCO) Meeting in Chicago, IL.

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