Changhoon Yoo, MD, PhD, Asan Medical Center, Seoul, Republic of Korea, discusses the results of a multinational, multicenter, retrospective study assessing clinical outcomes of patients with advanced hepatocellular carcinoma (HCC) who received subsequent systemic therapy after progression on atezolizumab-bevacizumab in Korea, Hong Kong, and Singapore. Second-line treatment with multikinase inhibitors demonstrated comparable efficacy and manageable toxicities in patients with advanced HCC after disease progression. This interview was recorded via an online conference call with The Video Journal of Oncology (VJOncology).