Adam Schoenfeld, MD, Memorial Sloan Kettering Cancer Center, New York, NY, discusses the need for improved therapies for patients with lung cancer and the potential role of chimeric antigen receptor T-cell (CAR-T) therapy, which has shown promising results in hematological malignancies. Dr Schoenfeld also highlights challenges of CAR-T therapy which are unique to solid tumors. This video was recorded at the virtual European Lung Cancer Congress (ELCC) 2021.