Triparna Sen, PhD, Memorial Sloan Kettering Cancer Center, New York, NY, discusses lineage plasticity and its implication in the development of lung cancer, as well as resistance to therapeutics. The results of an in-depth characterization of neuroendocrine transformation in lung cancer is presented and highlight a new landscape of potential drivers and targetable mutations of neuroendocrine transformation in lung cancer. This interview was recorded via an online conference call with The Video Journal of Oncology (VJOncology).