ESMO 2022 | POSEIDON: 4 year follow up of durvalumab and tremelimumab in NSCLC

Melissa Johnson, MD, Sarah Cannon Research Institute, Nashville, TN, discusses data from the 4 year follow up of the Phase III POSEIDON trial (NCT03164616) of durvalumab and tremelimumab in patients with metastatic non small-cell lung cancer (NSCLC). Patients were randomized to receive durvalumab and tremelimumab with chemotherapy, durvalumab monotherapy with chemotherapy or chemotherapy alone. In the follow up, long term survival was reported in the triple treatment arm, where patients with non-squamous, low PD-L1 NSCLC fared the best. Patients with hard to treat mutations such as STK11, KRAS and KEAP1 additionally reported favorable outcomes. This interview took place at the European Society for Medical Oncology (ESMO) 2022 Congress in Paris, France.

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