Enrique Grande, MD, MD Anderson Cancer Center Madrid, Madrid, Spain, highlights data coming from the DUTRENEO trial. This randomized phase II trial evaluated DUrvalumab and TREmelimumab versus chemotherapy as a NEOadjuvant approach in patients with muscle-invasive urothelial bladder cancer who were prospectively selected by an interferon-gamma immune signature. This interview was recorded via an online conference call with The Video Journal of Oncology (VJOncology).