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ASCO GI 2023 | Overcoming resistance to ICIs in biliary tract cancers

Rachna Shroff, MD, MS, University of Arizona College of Medicine, Tucson, AZ, shares strategies to enhance the efficacy of immune checkpoint inhibitors (ICIs) in patients with biliary tract cancers. Results from the TOPAZ-1 trial (NCT03875235) of durvalumab with gemcitabine and cisplatin have shown the efficacy of ICIs with chemotherapy. Additional trials such as the KEYNOTE-966 trial (NCT04003636) of pembrolizumab and others investigating atezolizumab and bevacizumab will also provide insight into the efficacy of this therapeutic modality. Alternative strategies include dual targeting of CTLA-4, PD-L1, or LAG-3. This interview took place at the American Society of Clinical Oncology (ASCO) 2023 Gastrointestinal Cancers (GI) Symposium in San Francisco, CA.

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