Shilpa Gupta, MD, Cleveland Clinic, Cleveland, OH, discusses the impact of primary tumor location, histology, and host factors on objective response to immune checkpoint inhibitors (ICIs) in metastatic urothelial carcinoma (mUC). The findings from this retrospective analysis, explained by Dr Gupta, showed no correlation between host and tumor factors, and treatment response or duration of response in patients. This interview took place during the 2021 Genitourinary Cancers Symposium.