Mark Yarchoan, MD, Johns Hopkins Medicine, Baltimore, MD, reflects on key updates presented at this year’s American Society of Clinical Oncology (ASCO) 2022 Annual Meeting, including the use of neoadjuvant immunotherapy in mismatch repair deficient colorectal cancer, as well as the continuing investigation of circulating tumor DNA (ctDNA). This interview took place at the American Society of Clinical Oncology (ASCO) 2022 Annual Meeting in Chicago, IL.