ASCO GI 2024 | Exploring durvalumab + bevacizumab + TACE in hepatocellular carcinoma: EMERALD-1 insights

Mark Yarchoan, MD, from Johns Hopkins University in Baltimore, MD, discusses the significance of the EMERALD-1 (NCT03778957) trial. The Phase III study explores the combination of durvalumab and bevacizumab with transarterial chemoembolization (TACE) in the intermediate setting for unresectable hepatocellular carcinoma. While it demonstrates safety and a progression-free survival (PFS) benefit, Dr Yarchoan emphasizes the need for longer follow-up to understand the durability of the benefits. He points out the absence of a TACE-free arm, raising the question of whether systemic therapy, as seen in this study, might replace TACE. This interview took place at the 2024 ASCO Gastrointestinal (GI) Cancers Symposium in San Francisco, CA.

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