ASCO GI 2024 | The evolving landscape of first-line therapies in advanced HCC

Mark Yarchoan, MD, Johns Hopkins University, Baltimore, MD, discusses the evolving landscape of first-line therapies in advanced hepatocellular carcinoma (HCC). Currently, durvalumab plus bevacizumab and atezolizumab plus bevacizumab are preferred regimens, with a potential third option being the IgG4, PD-1–directed monoclonal antibody camrelizumab in combination with the novel VEGFR2-directed tyrosine kinase inhibitor (TKI) rivoceranib, pending FDA approval. Additionally, the ongoing Phase III CheckMate-9DW (NCT04039607) trial comparing ipilimumab plus nivolumab to a tyrosine kinase inhibitor (TKI) might bring further changes to first-line options. This interview took place at the 2024 ASCO Gastrointestinal (GI) Cancers Symposium in San Francisco, CA.

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