Augusto Villanueva, MD, PhD, Icahn School of Medicine at Mount Sinai, New York, NY, expresses recent findings from two Phase III clinical trials (NCT01140347, NCT02435433) investigating patients with advanced hepatocellular carcinoma (aHCC) and high alpha-fetoprotein (AFP) treated with ramucirumab (RAM). The study aims to continue to investigate why aHCC patients with elevated AFP may be more responsive to treatment such as RAM and whether this has significant clinical relevance in terms of treatment guidelines for patients with aHCC. This interview was conducted at the American Society of Clinical Oncology (ASCO) 2021 Virtual Meeting.