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VJVirtual | BASECAMP-1: developing Tmod CAR T-cell therapy for solid tumors

Diane Simeone, MD, NYU Langone Health, New York, NY, discusses the observational BASECAMP-1 (NCT04981119) study investigating solid tumor analysis for HLA loss of heterozygosity (LOH) and apheresis for CAR T- cell manufacturing. Although CAR-T cell therapy has demonstrated clinical outcomes in hematological malignancies, translating engineered T-cell therapies to solid tumors has proven difficult due to a lack of tumor-specific targets. Tmod addresses these challenges via utilization of dual-signaling receptors to create a therapeutic safety window whilst enabling for the delivery of a heavy payload. In this study, patients will be initially screened to identify germline HLA-A*02 heterozygosity. If HLA-A*02 heterozygosity is confirmed, the tumor will be analyzed to determine whether HLA-A*02 loss of heterozygosity (LOH) is present. Those with confirmed HLA-A*02 LOH will be candidates for leukapheresis. Banked T cells will be available for the autologous Phase I/II EVEREST-1 (NCT05736731) Tmod CAR T-cell therapy interventional study. This interview was recorded via an online conference call with The Video Journal of Oncology (VJOncology).

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