SITC 2022 | Clinical applications of pentose phosphate pathway activation in immunotherapy

Recent research has revealed PKM2 inhibition to increase PD-1 blockade via activation of the pentose phosphate pathway. Geoffrey Markowitz, PhD, Weill Cornell Medicine, New York City, NY, describes the potential implications of PKM2 inhibition in the clinic. Various pentose phosphate antagonists are currently being tested in immune organoid models and tumor-infiltrating lymphocytes (TILs) can potentially be extracted from patients to be infused with pentose phosphate antagonists to enhance immune cell activity. This interview took place at the 37th Annual Meeting of the Society for Immunotherapy in Cancer (SITC 2022) in Boston, MA.

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