SITC 2022 | Enhancing PD-1 blockade by inhibiting PKM2 activity in the pentose phosphate pathway

Geoffrey Markowitz, PhD, Weill Cornell Medicine, New York City, NY, discusses the role of the pentose phosphate pathway in improving the efficacy of PD-1 checkpoint inhibitors. A screen of T cells in mouse lung cancer tissue revealed cells with high levels of TCF1 expression responding more to PD-1 inhibitors, and PKM2, an enzyme involved in both glycolytic and non-glycolytic pathways, was found to influence tumor control. Ongoing studies assessing AG1, an inhibitor of PKM2, have shown promising anti-tumor effects by increasing pentose phosphate pathway activity. This interview took place at the 37th Annual Meeting of the Society for Immunotherapy in Cancer (SITC 2022) in Boston, MA.

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