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ASCO GI 2023 | Targeting CLDN18.2 with zolbetuximab in gastric and GEJ cancer

Nataliya Uboha, MD, PhD, UW Carbone Cancer Center, Madison, WI, discusses findings from the SPOTLIGHT trial (NCT03504397), a Phase III study evaluating zolbetuximab, a claudin 18.2 targeting monoclonal antibody, plus modified (m)FOLFOX6 chemotherapy compared to placebo plus mFOLFOX6 as treatment for gastric and gastroesophageal junction (GEJ) cancer. The primary endpoint, progression-free survival, was met in addition to overall survival. This interview took place at the American Society of Clinical Oncology (ASCO) 2023 Gastrointestinal Cancers (GI) Symposium in San Francisco, CA.

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