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GU Cancers 2026 | Elucidating the future role of CDK4/6 inhibitors in renal cell carcinoma

David McDermott, MD, Beth Israel Deaconess Medical Center, Boston, MA, comments the limited current role of CDK4/6 inhibitors in kidney cancer, but suggests that future studies on other inhibitors could potentially lead to a more favorable risk-benefit profile. Reduce toxicity is important, and exploring other FDA-approved CDK4/6 inhibitors or pathway inhibitors in clinical development, may make this approach more viable. This interview took place at the 2026 ASCO GU Cancers Symposium in San Francisco, CA.

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Transcript

Well, right now it’s a limited role because even though both drugs are approved, we wouldn’t suggest using them based on this work, but we would suggest studying other inhibitors, you know, so potentially trying to figure out a way to say, for example, reduce the toxicity that was driven by the CDK4-6 inhibitor. There are other CDK4-6 inhibitors that are FDA approved, and as I mentioned, some pathway inhibitors are also in clinical development...

Well, right now it’s a limited role because even though both drugs are approved, we wouldn’t suggest using them based on this work, but we would suggest studying other inhibitors, you know, so potentially trying to figure out a way to say, for example, reduce the toxicity that was driven by the CDK4-6 inhibitor. There are other CDK4-6 inhibitors that are FDA approved, and as I mentioned, some pathway inhibitors are also in clinical development. If they were less toxic, that might be an approach that might make more sense because then the cost benefit would be more in favor of the increased toxicity. So I think there’s a future there, but it’s going to depend on future studies to get us there.

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