Whilst the advent of systemic therapies and immunotherapies have resulted in improved outcomes for patients with lung cancer, local control of the tumor remains an important focus. Charles Simone, MD, FACRO, New York Proton Center & Memorial Sloan Kettering Cancer Center, New York, NY, discusses strategies to improve multimodal treatment for patients with lung cancer to further optimize patient survival. Radiotherapy remains especially important for oligometastatic and oligoprogressive non-small cell lung cancer (NSCLC) and by improving dosage and radioprotective agents, patients can benefit more from multimodal therapies. This interview took place at the 2022 Targeted Therapies of Lung Cancer Meeting (TTLC 2022).