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ASCO 2024 | JNJ-6420, an anti-hK2 antibody–based targeted radiotherapy, in mCRPC

Michael Morris, MD, Memorial Sloan Kettering Cancer Center, New York, NY, discusses findings from a Phase I, first-in-human study (NCT04644770) evaluating JNJ-6420, an anti-hK2 antibody-based radiotherapy, in heavily pretreated patients with metastatic castration-resistant prostate cancer (mCRPC). Thrombocytopenia and interstitial lung disease were especially associated with repeated doses and durable responses were also noted, emphasizing hK2 as a promising target for prostate cancer therapy. This interview took place during the 2024 American Society of Clinical Oncology (ASCO) Meeting in Chicago, IL.

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