Cold stress has been investigated in preclinical mouse models, and we’ve seen that cold stress is associated with an immunosuppressive tumor microenvironment. But a similar study has not been undertaken in humans so far. So we conducted a cross-sectional analysis from patients who reported high stress using a prospective cohort from the ABC study. And there we interrogated that patients who were reporting high stress, what was actually going on in the tumor microenvironment...
Cold stress has been investigated in preclinical mouse models, and we’ve seen that cold stress is associated with an immunosuppressive tumor microenvironment. But a similar study has not been undertaken in humans so far. So we conducted a cross-sectional analysis from patients who reported high stress using a prospective cohort from the ABC study. And there we interrogated that patients who were reporting high stress, what was actually going on in the tumor microenvironment. Interestingly, we found differences by the ER subtype. So in the ER-positive breast cancer, we found that patients who were reporting stress, there was upregulation of the B cell receptor signaling pathway, as well as formation of more tertiary lymphoid structures. And in ER-negative breast cancer, we found that there was upregulation of the interferon gamma pathway. So as expected, stress and some of these other symptoms are associated with inflammation. And ours is the first study in humans that is showing this association of patient-reported stress with increased inflammatory signatures in the tumor microenvironment.
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