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ESMO 2025 | Treatment options for locoregional digestive neuroendocrine carcinomas
Juan Manuel O’Connor, MD, MSc, Instituto Alexander Fleming, Buenos Aires, Argentina, discusses the treatment of high-grade neuroendocrine carcinomas (NECs), focusing on localized and locally regional disease. A comprehensive approach consisting of surgery, radiation, and chemotherapy, as well as a deep understanding of the disease’s systemic nature are essential to determine the best strategy for patients. As this patient population has many potential treatment opportunities, a tailored approach is, therefore, needed. This interview took place at the European Society for Medical Oncology (ESMO) 2025 Congress in Berlin, Germany.
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Transcript
At ESMO 2025, I had the opportunity to discuss in this very nice special session, educational session based on the high-grade neuroendocrine carcinoma that is clearly an unmet need in this setting, also in neuroendocrine tumor fields. The treatment that I was discussing is in terms of the localized and locally regional disease, not in the setting of the advanced disease...
At ESMO 2025, I had the opportunity to discuss in this very nice special session, educational session based on the high-grade neuroendocrine carcinoma that is clearly an unmet need in this setting, also in neuroendocrine tumor fields. The treatment that I was discussing is in terms of the localized and locally regional disease, not in the setting of the advanced disease. I think that there are many opportunities for this patient, the surgical approach, radiation therapy, and also chemotherapy. For sure, it is very important to understand that it is a systemic disease so the most important thing is how to approach or what is the best strategy for this kind of patient.
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