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ASCO GI 2023 | LB1908: a novel CAR-T cell therapy targeting claudin 18.2 in GI malignancies

David Bing Zhen, MD, University of Washington Medicine, Seattle, WA, provides an overview of an open-label, Phase I trial (NCT05539430) of LB1908, an anti-claudin 18.2 CAR-T cell therapy, in patients with locally advanced and metastatic gastric, esophageal, gastroesophageal junction cancers. The first portion of the trial will assess safety and the recommended dose, whereas the second portion will involve dose expansion and include patients with pancreatic adenocarcinomas. This interview took place at the American Society of Clinical Oncology (ASCO) 2023 Gastrointestinal Cancers (GI) Symposium in San Francisco, CA.

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