David Bing Zhen, MD, University of Washington Medicine, Seattle, WA, describes the rationale behind targeting claudin 18.2 in gastrointestinal cancers. Claudin 18.2 is a tight-junction protein that is highly expressed in cancers, and has subsequently become a promising target. Dr Zhen highlights multiple monoclonal antibodies and cellular immunotherapies in development that may especially benefit pre-treated patients. This interview took place at the American Society of Clinical Oncology (ASCO) 2023 Gastrointestinal Cancers (GI) Symposium in San Francisco, CA.
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