Markus Hecht, MD, PhD, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany, talks on upcoming late phase clinical trials in head and neck cancer combining immune checkpoint blockade, including KEYNOTE-412 (NCT03040999), and discusses new strategies in combination approaches for patients with head and neck cancer. This interview took place at the American Society of Clinical Oncology (ASCO) 2021 Virtual Meeting.