Triparna Sen, PhD, Memorial Sloan Kettering Cancer Center, New York, NY, discusses upcoming small cell lung cancer (SCLC) trials assessing novel targets, including lysine-specific histone demethylase 1A (LSD1) inhibitors, enhancer of zeste homolog 1/2 (EZH1/2) inhibitors and DNA damage response inhibitors. This interview took place at the 2022 Targeted Therapies of Lung Cancer Meeting (TTLC 2022).